Fibronectin



Fibronectin (Fn) is a glycoprotein which binds extracellular matrix components like integrin, collagen, fibrin and others. It is a component of cell adhesion. It is a dimer of homologous monomers linked by S-S bond. Each monomer contains 3 types of modules: FnI, FnII and FnIII. Each module contains several numbered protein binding domains, i.e., 6FnI+1-2FnII is the gelatin binding domain (GBD). The images at the left and at the right correspond to one representative Fn, i.e. the crystal structure of human Fibronectin 4-5FnI fragment (1fbr).

Fn module FnI
3m7p – hFn GBD – human

1e8b, 1e88, 1qo6 - hFn GBD – NMR

3gxe, 3ejh – hFn 8-9FnI+collagen alpha-1

1fbr - hFn 4-5FnI

2rky, 2rl0 – hFn 4-5FnI+Fn binding peptide

2rkz, 3cal - hFn 2-3FnI+Fn binding peptide

2cg6, 2cg7 - hFn 2-3FnI

2cku - hFn 2-3FnI – NMR

1o9a - hFn 1-2FnI+B3 from FNBB – NMR

2ec3 – hFn 11FnI – NMR

1qgb – hFn FnI N-terminal - NMR

2ck2 – hFn (mutant) core swapped

1j8k – hFn extra domain 2 – NMR

1fnh – hFn heparin and integrin binding domains

2qbw, 3ch8 – hFn-PDZ fusion

Fn module FnII
2fn2 – hFn 2FnII – NMR

Fn module FnIII
1q38, 1x3d, 1x4x, 1x5x - hFn FnIII – NMR

2h41, 2h45 – hFn 2FnIII – NMR

1oww - hFn 1FnIII – NMR

2ha1 - hFn 1-2FnIII – NMR

2crm - hFn 4FnIII – NMR

2crz - hFn 5FnIII – NMR

1fna, 1ttf, 1ttg – hFn 10FnIII

2ocf - hFn 10FnIII+estrogen receptor ligand-binding domain

1fnf – hFn 7-10FnIII

2fnb – hFn FnIII ed-b domain – NMR

1mfn, 2mfn – Fn 9-10FnIII – mouse - NMR

2vmg, 2vmi - Fn FnIII carbohydrate-binding domain – Clostridium perfringens

Fn module FnI+FnII
3mql – hFn 6FnI+2FnII+7FnI